Measurement of Arterial Input Function in Hyperpolarized 13C Studies

Małgorzata Marjańska, Thomas Z. Teisseyre2, 3, Nicholas W. Halpern-Manners2, 4, Yi Zhang1, Isabelle Iltis1, Vikram Bajaj2, 4, Kamil Ugurbil1, Alexander Pines2, 4 and Pierre-Gilles Henry1

(1) Department of Radiology and Center for Magnetic Resonance Research, University of Minnesota, 2021 6th Street SE, Minneapolis, MN 55455, USA
(2) Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720, USA
(3) Joint Graduate Group in Bioengineering, UCSF and UC Berkeley, San Francisco, CA, USA
(4) Materials Sciences Division, E. O. Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

Received: 10 February 2012  Revised: 13 April 2012  Published online: 20 May 2012

Abstract

Recently, hyperpolarized substrates generated through dynamic nuclear polarization have been introduced to study in vivo metabolism. Injection of hyperpolarized [1-13C] pyruvate, the most widely used substrate, allows detection of time courses of [1-13C] pyruvate and its metabolic products, such as [1-13C] lactate and 13C-bicarbonate, in various organs. However, quantitative metabolic modeling of in vivo data to measure specific metabolic rates remains challenging without measuring the input function. In this study, we demonstrate that the input function of [1-13C] pyruvate can be measured in vivo in the rat carotid artery using an implantable coil.

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