Małgorzata Marjańska1 , Thomas Z. Teisseyre2, 3, Nicholas W. Halpern-Manners2, 4, Yi Zhang1, Isabelle Iltis1, Vikram Bajaj2, 4, Kamil Ugurbil1, Alexander Pines2, 4 and Pierre-Gilles Henry1
Received: 10 February 2012 Revised: 13 April 2012 Published online: 20 May 2012
Recently, hyperpolarized substrates generated through dynamic nuclear polarization have been introduced to study in vivo metabolism. Injection of hyperpolarized [1-13C] pyruvate, the most widely used substrate, allows detection of time courses of [1-13C] pyruvate and its metabolic products, such as [1-13C] lactate and 13C-bicarbonate, in various organs. However, quantitative metabolic modeling of in vivo data to measure specific metabolic rates remains challenging without measuring the input function. In this study, we demonstrate that the input function of [1-13C] pyruvate can be measured in vivo in the rat carotid artery using an implantable coil.
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