Why I decided to join GRAIL’s quest to detect cancer early

This month, I stepped down as Verily’s Chief Scientific Officer and joined GRAIL, a startup focused on the early detection of cancer, to guide its precision medicine and translational science efforts. I’ll still be affiliated with Verily through its Science Board, which I’ll chair. I write about the reasons for my decision here: Seeing deeply […]

Cover Article in JMR: Gradient-Free Microfluidic Flow Labeling Using Thin Magnetic Films and Remotely Detected MRI

Gradient-free microfluidic flow labeling using thin magnetic films and remotely detected MRI Nicholas W. Halpern-Manners, Daniel J. Kennedy, David R. Trease, Thomas Z. Teisseyre, Nicolas S. Malecek, Alexander Pines, Vikram S. Bajaj Abstract Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) may be employed as noninvasive measurements yielding detailed information about the chemical and […]

Cover Article, Angewandte Chemie: Ultra-Low-Field NMR Relaxation and Diffusion Measurements Using an Optical Magnetometer

Ultra-Low-Field NMR Relaxation and Diffusion Measurements Using an Optical Magnetometer Paul J. Ganssle, Hyun D. Shin, Scott J. Seltzer, Vikram S. Bajaj, Micah P. Ledbetter, Dmitry Budker, Svenja Knappe, John Kitching, and Alexander Pines ABSTRACT Nuclear magnetic resonance (NMR) relaxometry and diffusometry are important tools for the characterization of heterogeneous materials and porous media, with applications […]

Nature Communications: Optical Hyperpolarization and NMR Detection of 129Xe on a Microfluidic Chip

Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip Ricardo Jiménez-Martínez, Daniel J Kennedy, Michael Rosenbluh, Elizabeth A Donley, Svenja Knappe, Scott J Seltzer, Hattie L Ring, Vikram S Bajaj, John Kitching     ABSTRACT Optically hyperpolarized 129Xe gas has become a powerful contrast agent in nuclear magnetic resonance (NMR) spectroscopy and imaging, with […]

Nature Communications: Optically Detected Cross-relaxation Spectroscopy of Electron Spins in Diamond

Optically detected cross-relaxation spectroscopy of electron spins in diamond Hai-Jing Wang, Chang S. Shin, Scott J. Seltzer, Claudia E. Avalos,  Alexander Pines, and Vikram S. Bajaj   ABSTRACT The application of magnetic resonance spectroscopy at progressively smaller length scales may eventually permit ‘chemical imaging’ of spins at the surfaces of materials and biological complexes. In […]

New Publication in Physical Review B: Optically Detected Nuclear Quadrupolar Interaction of 14N in Nitrogen-vacancy Centers in Diamond

Optically Detected Nuclear Quadrupolar Interaction of 14N in Nitrogen-vacancy Centers in Diamond Chang S. Shin, Mark C. Butler , Hai-Jing Wang , Claudia E. Avalos, Scott J. Seltzer, Ren-Bao Liu , Alexander Pines , and Vikram S. Bajaj   ABSTRACT We report sensitive detection of the nuclear quadrupolar interaction of the 14N nuclear spin of […]

New publication in Nature Chemistry: Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging

  Genetically encoded reporters for hyperpolarized xenon magnetic resonance imaging Mikhail G. Shapiro, R. Matthew Ramirez, Lindsay J. Sperling, George Sun, Jinny Sun, Alexander Pines, David V. Schaffer and Vikram S. Bajaj     ABSTRACT Magnetic resonance imaging (MRI) enables high-resolution non-invasive observation of the anatomy and function of intact organisms. However, previous MRI reporters of […]

JACS Article: Hyperpolarized xenon-based molecular sensors for label-free detection of analytes

Hyperpolarized xenon-based molecular sensors for label-free detection of analytes Praveena D. Garimella, Tyler Meldrum, Leah Suzanne Witus, Monica Smith, Vikram Singh Bajaj, David E Wemmer, Matthew B Francis, and Alexander Pines ABSTRACT: Nuclear magnetic resonance (NMR) can reveal the chemical constituents of a complex mixture without re- sorting to chemical modification, separation, or other perturbation. Recently, […]

JACS Publication: Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy

Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy Galia T. Debelouchina, Marvin J. Bayro, Anthony W. Fitzpatrick, Vladimir Ladizhansky,  Michael T. Colvin, Marc A. Caporini, Christopher P. Jaroniec, Vikram S. Bajaj, Melanie Rosay, Cait E. MacPhee, Michele Vendruscolo, Werner E. Maas, Christopher M. Dobson, Robert G. Griffin* Abstract Protein magic angle spinning […]

Little evidence for health effects of contaminated fish following Fukushima accident

Recent reports in the popular press cite evidence for contamination of tuna and other fish by unnatural radionuclides released after the Fukushima nuclear disaster.  These reports occasionally assert possible consequences to human health, usually without context or reference to rigorous, evidence-backed models. Some reports state that the mere presence of these elements is dangerous without […]